Ngarootaha

Hokona Linaclotide i te utu iti. Kounga teitei. Utu iti. Uiui Inaianei!
Tikina Linaclotide mo te hoko; Tikina te Utu Linaclotide Mai i te Kaihanga/Kaiwhakarato;Tuhinga, Mahi - Bolise.

[Raupapa] H-Cys-Cys-Glu-Tyr-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH cyclic (1-6), (2-10), (5- 13) -tris (disulfide)
[Cas KORE. ] 851199-59-2
[Tātai Molecular] C59H79N15O21S6
[Taumaha Molecular] 1526.73
[Ahua] Paura Ma
[Pure] 98%

[Tono]
Mo te ako mo te mate pukupuku irritable bowel with constipation (IBS-C) me te koroka roa.

Mo Linaclotide
Ko Linaclotide he guanylate cyclase-C receptor agonist (GCCA) me te analgesic visceral me te mahi endocrine. Ka taea e te linaclotide me ona metabolites kaha te here ki nga kaiwhiwhi cyclase-C (GC-C) guanylate i runga i te mata maramara o te epithelium intestinal iti. I roto i nga tauira kararehe, na roto i te whakahohenga o te GC-C, ka taea e linaclotide te whakaiti i te mamae o te visceral me te whakapai ake i te tere whakawhiti gastrointestinal. I roto i te tangata, ka taea hoki e te tarukino te whakanui ake i te tere whakawhiti intestinal. Ko te hua o te whakahohenga GC-C ka piki ake te whakaurunga intracellular me te extracellular cGMP (cyclic guanosine monophosphate). Ka taea e te cGMP extracellular te whakaheke i te mahi o nga muka nerve mamae me te whakaora i te mamae visceral i roto i nga kararehe tauira. Ka taea e te cGMP Intracellular te whakanui ake i te whakamaarama o te chloride me te bicarbonate i roto i te lumen o te whekau iti ma te whakahohe i te CFTR (cystic fibrosis transmembrane conductance regulator), i te mutunga ka arahi ki te piki haere o te wai o te whekau iti me te tere o te whakawhiti intestinal.