E-304

Hokona te Paura O-304 i te Utu Hokomaha. Kei te Hokohia te O-304 me te Kounga Teitei me te Utu Iti Rawa. Uiui Inaianei!
Tukunga Wheketere. Hokona te O-304 Ipurangi mai i te Kaihanga/Kaituku, Ngā Painga, Te Utu - Bolise.

[CAS KORE. ] 1261289-04-6
[ Tātai Ngota ] C16H11Cl2N3O2S
[Taumaha Molecular] 380.2
[Ahua] Paura Ma
[Pure] ≥98%

[ Āhuatanga]
1. Teitei o te parakore: Ka hangaia te O-304 mā te tukanga hanga kua whakatikatikaina, kia eke ki te teitei o te parakore o te hua. Ko te tikanga o te parakore teitei he pai ake te wātea o te koiora.
2. Te Mahi Koiora: Ka whakarei ake a O-304 i te mahi AMPK mā te aukati i te tangohanga o te phosphorylation o PAMPK.

[Tono]
1. Whakahohenga AMPK: 
Ka whakanuia e te O-304 te mahi AMPK mā te aukati i te tukanga tangohanga phosphorylation o te AMPK kua whakapūtāhia (pAMPK), ā, mā reira ka whakahaere i te taurite o te pākia o te pūngao.
2. Te whakapai ake i te pākia o te huka:
I roto i ngā rangahau kararehe, i āwhina te horopeta o te 100 mg/kg o te O-304 ki te pupuri i te taumata huka toto nohopuku me te taumata insulin plasma pumau, ā, i whakaiti nui i te taumahatanga pākia e te kai nui-ngako, me te ārai i ngā piki me ngā heke o te huka toto me te pikinga o te insulin rerekē i puta mai i te kore taurite o te kai.
3. Te tiaki i te ngāwari o ngā uaua toto: 
Ka āwhina te O-304 ki te pupuri i te toto toto ki ngā taumata hauora, ka whakaiti i te ahotea ki ngā oko toto, ā, ka whakarato i te tiakitanga ngawari mō te wā roa mō ngā pūnaha ngakau me te roro, me te tautoko i te pumau o ngā kare ā-roto me te pūngao pumau.
4. Te whakatairanga i te taitamarikitanga pumau: 
Ka aro tika a O-304 ki te ara tohu AMPK-mTOR, ka whakahaere atamai i te tukanga o te autophagy pūtau, ka whakatairanga i te catabolism o ngā pūmua kua koroheketia me ngā lipids rerekē, me te pupuri i te taiao pūtau ma, oraora hoki, ā, ka whakaroa i te koroheketanga pūtau.

Mō O-304
He kaiwhakaoho AMPK ngota iti te O-304 e whakarei ake ana i te mahi AMPK mā te aukati i te tangohanga o te phosphorylation o te AMPK phosphorylated (pAMPK), ā, ka whakanui ake i ngā taumata pAMPK me te kore e whakaiti i ngā kukū adenosine triphosphate (ATP) i roto i te pūtau. He maha ngā tikanga mahi a ia, tae atu ki te whakapai ake i te pākia o te huka, te whakaiti i te ātete ki te insulin, me te tiaki i te pūnaha manawa.
He matū ngota iti te O-304 e aro ana ki te AMPK (adenosine monophosphate-activated protein kinase). Mā te whakahohe i ngā ara pākia o te pūngao ā-roto, ka whai i ngā pānga ā-tinana o te whakakori tinana, pērā i te whakapai ake i te ātete ki te insulin me te whakarei ake i te mahi a te ngākau. Ko tōna hiranga matua ko te whakarato i tētahi atu wawaotanga mō ngā tāngata kāore e taea te whai hua mai i te whakakori tinana (pērā i te kaumātua, i te hunga rānei he mate pūmau).
Ka whakanui ake a O-304 i te mimiti o te huka i roto i te uaua angaanga, ka whakaiti i te ahotea o ngā pūtau-β, ā, ka whakatairanga i te okiokinga o ngā pūtau-β i roto i ngā kiore momona i puta mai i te kai. I roto i tētahi whakamātautau haumanu wāhanga IIa mō te whakamātautau haumanu i roto i ngā tūroro mate huka momo 2 (T2D) i rongoatia ki te metformin, i whakaitihia e O-304 ngā taumata huka toto nohopuku me te Aromatawai Tauira Homeostatic o te Ātete Insulin (HOMA-IR).