Ceramide

[Ahua] Paura Ma
Mo Ceramide
Ko nga rangahau haumanu i roto i te taatai ​​kua whakaatuhia mai i te nuinga o nga wa o te kiri penei i te atopi, te hakihaki me te psoriasis e hono ana ki te taumata o raro o te Ceramides i roto i te stratum corneum i te kiri noa.
Ka kitea pea he ceramides hei whakauru i etahi rongoa kiri o te kiri hei whakamahi hei whakakapi i te rongoa mo nga kiri penei i te eczema.
Ko te Ceramide, e mohiotia ana ko te sphingolipid, he ngutu e kitea ana i roto i te kiri, he mea nui ki te hanga stratum corneum o te epidermis He waahanga hanganga e tohaina ana e te (nerve) sphingolipids. Ko te waikawa momona he hanganga waikawa amide waikawa kei runga i te roopu amino o te sphingosine. Mena ka herea ki te huka, ka waiho hei glycosphingolipid, ana ka herea ki te kowhiri, ka waiho hei (neuro) sphingomyelin. Ko te Ceramide he metabolite takawaenga o te sphingolipids, ina koa he tuunga nui kei roto i te koiora. He iti noa te moni kei waho o nga peara. I nga tuuroro e pangia ana e te mate Fabry, tetahi o nga mate lipid lipid tuku iho, he nui te ceramide kei te whakaemihia i te cerebellum me te whatukuhu. E ai ki nga rangahau o tenei wa ka maroke te kiri, ka kore te mana, ka pakaru, ka tino whakaitihia te aukati, ka taea e te taapiri kiri me te ceramide te whakahoki mai i te ngoikoretanga me te aukati.
He nui te mahi a te Ceramide ki te whakauru i nga koiora koiora penei i nga momo cytokine, huaora D3, Fas me nga kikii CD28, ana ko tana mahi ki te takawaenga i te apoptosis he mea whakamere. I te wa ano, kei roto hoki te ceramide i nga momo momo mahi tinana penei i te rereketanga o te pūtau. Tukanga Pathological. Ka taea e te Ceramide te whakaputa apoptosis i te wa o te ahurea keratinocyte epidermal. Ko te Ceramide he hua na te whakakorenga o te sphingomyelin kei roto i te bofile biofilm a e mohiotia ana ko ia te karere tuarua; he nui te mahi a te ceramide ki te tipu o te pūtau, te tini haere, te wehewehe, te apoptosis me te whara.